In China, the history of consuming ginger is long. According to the "Shennong Materia Medica Classic", "dried ginger has a pungent and warm taste, which mainly affects the chest, coughs, reflux, and upper qi. It is warm and stops bleeding, and is considered to have the effects of dehumidification and nourishment." Ginger is not only used as a daily ingredient, but also a medicinal herb in traditional Chinese medicine.
It is precisely this kind of food that has a history of more than two thousand years in China and is still active in our Chinese plates. Recently, it has been further studied and cracked by American scientists, and finally found to have a close relationship with "inhibiting aging".
In March of this year, the National Institute on Aging (NIA) published a study in the journal PLOS ONE, which showed that a component extracted from ginger, gingerol A, can induce cell apoptosis and clear 50% of aging cells within 2 days.
Aging cells are the "source of pollution" in the human body. According to the Time School of the Fudan anti-aging research team, they come from normal cells that have run out of energy. They not only lose their own activity, but also affect the surrounding healthy cells, leading to the decline of human overall function. Therefore, they are also known as "zombie cells".
In fact, Senolytics is recognized by the scientific community as a direct and efficient aging intervention method. A study published in Nature in February 2016 showed that by accurately locating and eliminating aging cells, the average lifespan of organisms is extended by about a quarter, and the longest can even reach over one-third.
Previously, the traditional clearance method was mostly the combination of D+Q (dasatinib and quercetin), and the strong combination of the two could eliminate about 30% of aging cells. It was rated as one of the "Top 10 Global Breakthrough Technologies" in the 2020 MIT Review, but it has a major fatal flaw - "toxicity" is not small.
The experimental researchers at NIA used D+Q as the control group and ginger as the experimental group. It was quickly discovered that although D+Q was indeed effective in clearing aging cells, at the same time, surrounding healthy cells were also subjected to indiscriminate attacks, greatly reducing cell proliferation activity and inevitably causing significant damage to their vitality. Therefore, traditional D+Q combinations are not the best choice.
Figure caption: Effects of control group (DMSO), dasatinib+quercetin (D+Q), 6-Shogaol, and Gingerenone A on proliferating cells (gray) and aging cells (red)
In the ginger group, the researchers applied 20 μ After operating on aging cells in the human body, it was surprising to find that the ginger extract (gingerol A) with a concentration ratio of M was even better than the traditional ace combination D+Q in clearing aging cells. Not only did it not accidentally harm surrounding healthy cells, but it also significantly increased cell division activity, achieving an unexpected joy of "1+1>2".
So, can ginger extract, which has an amazing clearing effect, become a new generation of challengers for Senolytics, igniting the "Senolytics family"? In fact, as early as 2016, Amazon founder Bezos invested $3 billion in a biotech company called Unity Biotechnology, which also focuses on Senolytics. Unfortunately, the second phase clinical trial of the company's research and development achievement UBX0101 ended in failure last year, and drug development also came to a halt. On that day, the stock price of Unity plummeted sharply, with a market value evaporating nearly $200 million.
However, the energy molecule that activates cells (the core component of "Seryl") that emerged from Harvard Medical Laboratory is a research achievement that truly emerged from the laboratory and successfully targeted the public. This exciting discovery, once published in Cell, caused a huge stir in the international academic community. It has also been continuously followed up by human clinical trials such as the University of Tokyo and Keio University, further confirming the enormous potential of this molecule in delaying aging.
It is reported that the energy activation results of this cell were first applied in the severely affected aging area of Japan and officially included in the local food list in 2018. Not long after, Nissan's Cerro products emerged in response to the huge demand for elderly people in the local area, and also became popular among high net worth individuals in China through channels such as JD.com. According to the time school data of Fudan anti-aging research team, as the basic unit of organism, the aging process of cells affects the whole body. The achievements of Nissan Serena are to reverse aging and increase life mileage by revitalizing the cell activity of the elderly population.
Post time: Dec-17-2023