In modern society, electronic devices such as mobile phones, computers, and tablets have become indispensable tools for people's daily work and life. Using these electronic devices for a long time can make people feel uncomfortable in their eyes, reduce their vision, and some people will suffer from dry eye syndrome. Epidemiological studies show that the incidence rate of dry eye syndrome in my country is 21%-30%. Even though the risk of cardiovascular disease increases with age, retinal ischemia mediated by cardiovascular abnormalities can lead to severe visual impairment.
Faced with various possible hazards to the eyes in life, taking NMN may be a way for us to protect our eyes.
NMN reduces inflammation in dry eye disease
In February 2021, a domestic research team published a study in the Journal of Inflammation Research. Studies have shown that NMN has a significant protective effect on eye cells under high-salt conditions similar to dry eye syndrome.
Hyperosmotic stress (HS) is a key pathological factor in the occurrence of dry eye disease (DED). The researchers produced a NaCl-based HS in vitro model (163 mOsm) and co-cultured it with corneal epithelial cells (CEC) and the macrophage cell line RAW500.264. The researchers studied the effects of NMN on NAD+ metabolism and expression of the HS biomarker tension response element binding protein (TonEBP).
The results showed that NMN treatment increased NAD+ concentration, thereby improving cell viability, reducing apoptosis rate, and reducing LDH release in HS-treated CECs. NMN can also alleviate HS-induced release of MMP, intracellular ROS and LDH. In addition, based on the CEC-macrophage co-culture system, NMN can improve SIRT1 function and reduce the expression of HS-related IL-17a in CEC, thereby alleviating macrophage phagocytosis and M1 polarization. NMN treatment can modulate macrophage activation through the Notch pathway in CECs.
The results indicate that NMN can alleviate the HS-induced DED state by regulating CEC/macrophage interactions. Research data also pointed out the role of NMN in the SIRT1, IL-17a, and Notch pathways, showing that NMN alleviated hyperosmotic-induced IL-17a secretion and macrophage activation in a corneal epithelial cell/macrophage co-culture system.
NMN prevents retinal dysfunction
Post time: Nov-17-2023